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. 2022 May 29;13(5):13162–13173. doi: 10.1080/21655979.2022.2074109

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Knockdown of SIRT3 abolished the protective effects of Sitagliptin in H9c2 cardiomyocytes. Cells were transfected with SIRT3 siRNA, followed by stimulation with H/R in the presence or absence of Sitagliptin (100 nM) for 6 h. (a). Western blot analysis revealed successful knockdown of SIRT3; (b). The expression of Parkin, LC3 II/LC3 I, Beclin1, and NIX; (B). Levels of CK-MB (^###, P < 0.001 vs. vehicle group; ^$$, P < 0.01 vs. H/R group; ***, P < 0.001 vs. H/R+ Sitagliptin group, mean ± S.D., N = 5).