Table 3.
Effect of RV on systemic inflammation markers in patients with aggressive periodontitis.
| Parameters (pg/ml) | Placebo (n = 40) | LRV (n = 40) | MRV (n = 40) | HRV (n = 40) |
| TNF-α | 625 ± 210 | 112 ± 102∗∗ | 108 ± 118∗∗ | 104 ± 98∗∗ |
| GMCSF | 762 ± 120 | 270 ± 121∗∗ | 256 ± 108∗∗# | 246 ± 110∗∗ |
| MIP-1α | 632 ± 168 | 183 ± 68∗∗ | 172 ± 75∗∗ | 165 ± 60∗∗ |
| Fibrinogen | 354 ± 124 | 124 ± 65∗∗ | 118 ± 54∗∗ | 110 ± 48∗∗ |
| IL-2 | 878 ± 168 | 242 ± 88∗∗ | 220 ± 94∗∗ | 212 ± 84∗∗ |
| CRP | 3028 ± 425 | 1326 ± 324∗∗ | 1245 ± 310∗∗ | 1222 ± 286∗∗ |
| INF-γ | 375 ± 132 | 168 ± 78∗∗ | 160 ± 80∗∗ | 156 ± 65∗∗ |
| IL-1β | 543 ± 150 | 220 ± 105∗∗ | 210 ± 90∗∗ | 196 ± 68∗∗ |
| IL-8 | 756 ± 210 | 354 ± 142∗∗ | 350 ± 152∗∗ | 326 ± 137∗∗ |
| IL-10 | 430 ± 162 | 186 ± 54∗∗ | 350 ± 152∗∗ | 326 ± 137∗∗ |
| IL-12p40 | 518 ± 125 | 225 ± 108∗∗ | 216 ± 114∗∗ | 204 ± 108∗∗ |
| MCP-1 | 334 ± 118 | 538 ± 127∗∗ | 552 ± 140∗∗ | 567 ± 134∗∗ |
| IL-4 | 246 ± 95 | 414 ± 146∗∗ | 454 ± 150∗∗ | 470 ± 160∗∗ |
| IL-6 | 285 ± 100 | 456 ± 142∗∗ | 486 ± 162∗∗ | 493 ± 172∗∗ |
Data are expressed as mean ± SD and analyzed using ANOVA with Dunn's multiple comparisons. ∗∗P < .01 vs. placebo.
CRP = C-reactive protein, GMCSF = granulocyte-macrophage colony stimulating factor, HRV = high dose RV, IL-1β = interleukin-1alpha, IL-2 = interleukin-2, IL-10 = interleukin-10, IL-12p40 = interleukin-12p40, MCP-1 = monocyte chemoattractant protein-1, IL-4 = interleukin-4, IL-6 = interleukin-6, IL-8 = interleukin-8, LRV = low dose RV, INF-γ = interferon-gamma, MIP-1α = macrophage inflammatory protein-1alpha, MRV = middle dose RV, TNF-α = tumor necrosis factor-alpha.