Table 4.
Effect of RV on local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis.
| Parameters (pg/ml) | Placebo (n = 40) | LRV (n = 40) | MRV (n = 40) | HRV (n = 40) |
| TNF-α | 415 ± 101 | 174 ± 96∗∗ | 124 ± 118∗∗ | 104 ± 98∗∗ |
| GMCSF | 510 ± 205 | 266 ± 121∗∗ | 240 ± 99∗∗# | 232 ± 92∗∗ |
| MIP-1α | 444 ± 122 | 175 ± 78∗∗ | 170 ± 70∗∗ | 155 ± 53∗∗ |
| Fibrinogen | 410 ± 130 | 202 ± 85∗∗ | 189 ± 80∗∗ | 182 ± 81∗∗ |
| IL-2 | 506 ± 227 | 322 ± 105∗∗ | 310 ± 110∗∗ | 297 ± 97∗∗ |
| CRP | 878 ± 185 | 340 ± 132∗∗ | 320 ± 140∗∗ | 307 ± 126∗∗ |
| INF-γ | 296 ± 45 | 152 ± 38∗∗ | 140 ± 43∗∗ | 127 ± 40∗∗ |
| IL-1β | 408 ± 144 | 175 ± 80∗∗ | 172 ± 76∗∗ | 163 ± 55∗∗ |
| IL-8 | 356 ± 116 | 142 ± 70∗∗ | 128 ± 67∗∗ | 114 ± 43∗∗ |
| IL-10 | 246 ± 135 | 107 ± 38∗∗ | 105 ± 52∗∗ | 101 ± 46∗∗ |
| IL-12p40 | 422 ± 138 | 182 ± 96∗∗ | 168 ± 77∗∗ | 158 ± 60∗∗ |
| MCP-1 | 426 ± 129 | 655 ± 154∗∗ | 668 ± 172∗∗ | 685 ± 180∗∗ |
| IL-4 | 136 ± 42 | 360 ± 124∗∗ | 377 ± 144∗∗ | 386 ± 152∗∗ |
| IL-6 | 342 ± 105 | 610 ± 179∗∗ | 635 ± 198∗∗ | 550 ± 202∗∗ |
| Endotoxin (EU) | 2.86 ± 0.72 | 1.04 ± 0.35∗∗ | 0.69 ± 0.20∗∗# | 0.63 ± 0.22∗∗# |
Data are expressed as mean ± SD and analyzed using ANOVA with Dunn's multiple comparisons. ∗∗P < .01 vs. placebo, #P < .05 vs. LRV.
CRP = C-reactive protein, GMCSF = granulocyte-macrophage colony stimulating factor, HRV = high dose RV, IL-1β = interleukin-1alpha, IL-2 = interleukin-2, IL-10 = interleukin-10, IL-12p40 = interleukin-12p40, IL-4 = interleukin-4, IL-6 = interleukin-6, IL-8 = interleukin-8, LRV = low dose RV, INF-γ = interferon-gamma, MIP-1α = macrophage inflammatory protein-1alpha, MRV = middle dose RV, TNF-α = tumor necrosis factor-alpha.