Table 4.
Multivariable logistic regression models for deterioration of estimated glomerular filtration rate.
| Univariate analysis | Multivariate analysis | ||||
| Factor | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | >70 yr | 1.288 (0.539–3.079) | .569 | ||
| Sex | Male | 0.917 (0.311–2.701) | .875 | ||
| BMI | >22.30 kg/m2 | 2.619 (1.077–6.372) | .034 | 2.120 (0.855–5.255) | .104 |
| Diabetes mellitus | + | 1.462 (0.533–4.007) | .461 | ||
| Hypertension | + | 1.556 (0.634–3.816) | .335 | ||
| Pretreatment diuretics use | + | 2.577 (0.884–7.515) | .083 | ||
| Diuretics addition or increase during treatment | + | 1.720 (0.481–6.156) | .405 | ||
| Etiology | NBNC | 0.668 (0.275–1.620) | .372 | ||
| Performance status | 1/2 | 0.961 (0.342–2.704) | .940 | ||
| Child-Pugh grade | B | 2.867 (0.868–9.465) | .084 | ||
| BCLC stage | C | 0.943 (0.388–2.294) | .897 | ||
| Platelet count | <15.4 × 104/μL | 1.000 (0.421–2.373) | 1.000 | ||
| PT | <87% | 0.895 (0.377–2.125) | .801 | ||
| T.bil | >0.9 mg/dL | 1.215 (0.511–2.886) | .659 | ||
| Albumin | <3.5 g/dL | 0.636 (0.265–1.530) | .312 | ||
| ALT | >27 IU/mL | 0.510 (0.212–1.226) | .132 | ||
| AFP | > 77.0 ng/mL | 1.000 (0.421–2.373) | 1.000 | ||
| Sodium | <140 mEq/l | 0.614 (0.254–1.489) | .281 | ||
| BUN | > 14 mg/dl | 0.972 (0.407–2.321) | .949 | ||
| Creatinine | >0.8 mg/dL | 2.275 (0.936–5.526) | .070 | ||
| eGFR | <71.70 mL/min/1.73 m2 | 2.200 (0.911–5.316) | .080 | ||
| Thyrosine kinase inhibitor | Lenvatinib | 2.700 (1.106–2.701) | .029 | 2.547 (1.028–6.315) | .043 |
AFP = alpha fetoprotein, ALT = alanine aminotransferase, BCLC = Barcelona Clinic liver cancer, BMI = body mass index, BUN = blood urea nitrogen, eGFR = estimated glomerular filtration rate, PT = prothrombin, T.bil = total bilirubin.