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. 2022 Mar 3;135(7):757–766. doi: 10.1097/CM9.0000000000002100

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Macrophages in AKI-to-CKD progression. Macrophages derived from bone marrow are recruited into the injured kidney and promote AKI-to-CKD by directly and indirectly Interacting with intrinsic kidney cells and via the process of MMT. AKI: Acute kidney injury; BRP: Breast regression protein; CKD: Chronic kidney disease; DAMPs: Damage-associated molecular patterns; MMT: Macrophage-myofibroblast transition; ECM: Extracellular matrix; MMP: Matrix metalloproteinase; M1: Macrophage 1 phenotype; M2: Macrophage 2 phenotype; Mø: Resident macrophage; TGF-β: Transforming growth factor-β.