Table 4.

Logistic regression analyses for progression to severe COVID-19.

Variable (N = 239)	No progression (Grade 1)	Progression (Grade 2–6)	Unadjusted			Adjusted
			Unadjusted OR	95% CI	P-value	Adjusted OR	95% CI	P-value
Age
<60	96	9	4.551	2.047–10.117	.001∗	3.801	1.545–9.350	.004∗
≥60	75	32
Sex
Female	106	26	0.941	0.464–1.907	.866	0.913	0.408–2.044	.824
Male	65	15
History of MI
No	170	40	4.250	0.260–69.411	.310	4.626	0.255–54.084	.301
Yes	1	1
Congestive heart failure
No	171	41	–	–	–	–	–	–
Yes	0	0
PAOD
No	171	41	–	–	–	–	–	–
Yes	0	0
History of CVA
No	165	35	4.714	1.436–15.479	.011∗	3.906	0.862–17.703	.077
Yes	6	6
Dementia
No	159	34	2.728	1.001–7.438	.050∗	1.861	0.585–5.924	.293
Yes	12	7
COPD
No	170	40	4.250	0.260–69.411	.310	1.797	0.021–152.183	.796
Yes	1	1
Connective tissue diseases
No	168	41	–	–	–	–	–	–
Yes	3	0
Peptic ulcer disease
No	169	41	–	–	–	–	–	–
Yes	2	0
Chronic liver diseases
No	169	41	–	–	–	–	–	–
Yes	2	0
Diabetics mellitus
No	147	27	3.176	1.461–6.904	.004∗	2.029	0.861–4.782	.106
Yes	24	14
Hemiplegia
No	168	39	2.872	0.464–17.774	.257	0.691	0.228–2.097	.515
Yes	3	2
Chronic kidney diseases
No	169	40	2.112	0.187–23.878	.546	1.548	0.484–6.391	.391
Yes	2	1
Solid organ tumor
No	167	39	2.141	0.379–12.111	.389	1.548	0.183–13.090	.688
Yes	4	2
Leukemia
No	171	41	–	–	–	–	–	–
Yes	0	0
Lymphoma
No	171	41	–	–	–	–	–	–
Yes	0	0
AIDS
No	171	41	–	–	–	–	–	–
Yes	0	0
EBV viremia
No	145	37	0.603	0.198–1.835	.373	0.340	0.099–1.164	.086
Yes	26	4

CI = confidence interval, COPD = chronic obstructive pulmonary disease, CVA = cerebrovascular accident, EBV = Epstein–Barr virus, Grade 1 = symptomatic but no oxygen therapy required, Grade 2 = low-flow nasal cannula, Grade 3 = high-flow nasal cannula/non-invasive ventilation, Grade 4 = mechanical ventilation, Grade 5 = extracorporeal membrane oxygenation, Grade 6 = death, MI = myocardial infarction, OR = odds ratio, PAOD = peripheral arterial occlusive disease.