Table 1.

Staging of cervical cancer, treatment and related fertility preservation approach.

UCC Stage	Treatment	Fertility preservation approach
Early disease
IA1	Conization	Conization
IA2, IB, IIA	Combined radiation with brachytherapy and radical hysterectomy with lymphadenectomy	Fertility sparing surgery (Radical vaginal trachelectomy with pelvic lymph node dissection)
	Cisplatin-based chemotherapy with radiation (if high-risk features as positive lymph nodes, surgical margins and/or parametria
Advanced disease
IIB, III, IVA	Cisplatin-based chemotherapy with radiation	Ovarian suppression with GnRHa before/during CHT Ovarian transposition before RT Oocyte cryopreservation before neo-adjuvant CHT or combined CHT-RT Ovarian cortex cryopreservation In vitro differentiation of OSCs
Metastatic disease
IVB, recurrent cancer	Cisplatin as palliative, radiation therapy for control of bleeding and pain and systemic chemotherapy for disseminated disease	Although it is ethically inadvisable, it is nonetheless applicable a gestional surrogacy