FIG. 4.

Alignment of nucleotide sequences of Sth3681 and LlaKR2I R-M systems. Sth368I corresponds to the actual intergenic sequence of the Sth368I R-M system of S. thermophilus CNRZ368. LlaKR2I corresponds to the intergenic sequence of the LlaKR2I R-M system, where the entire IS982 and a copy of the sequence duplicated after the IS982 insertion (5′-TATCATT-3′) were deleted to allow comparison. The remaining copy of the duplication created by IS982 transposition is indicated (DR IS982). The dots in the LlaKR2I sequence indicate the positions which are identical in the Sth368I and LlaKR2I intergenic sequences. The dashed lines indicates gaps. The ATG start codons of endonuclease- and methyltranferase-encoding genes are labeled by arrows indicating the direction of transcription. The shaded areas indicate putative RBSs or putative −10 and −35 consensus sequences. The sequence 5′-GATC-3′ found in the −35 motif preceding sth368IM and llaKR2IM is written in lowercase.