Table 2.
Frequency of ESR1 and ESR2 genes genotypes in cases and controls.
| Genotypes | |||||||||
| Ethics | SNPs, rs, (A > B) | Case (AA/AB/BB) | Control (AA/AB/BB) | OR [95% CI], P (Addmodel) BB/AA | P a (adj) | OR [95% CI], P (Dommodel) BB+AB/AA | P a (adj) | OR [95% CI], P (Recmodel) BB/AB+BB | P a (adj) |
| ESR1 | rs9340799 (A > G) | 168/75/15 | 149/97/18 | 0.59[0.17–2.01],.40 | – | 1.40[0.41–4.69],.58 | – | 0.61[0.33–1.13],.12 | |
| rs2234693 (T > C) | 96/110/51 | 105/111/48 | 1.29[0.57–2.94],.53 | – | 0.78[0.37–1.64],.52 | – | 1.11[0.61–2.05],.73 | ||
| rs3798759 (A > C) | 132/96/30 | 134/99/31 | 0.75[0.29–1.90],.54 | – | 1.20[0.49–2.94],.69 | – | 0.76[0.42–1.37],.36 | ||
| ESR2 | rs4986938 (C > T) | 208/44/6 | 195/60/9 | 0.42[0.08–2.22], – | – | 2.53[0.48–13.41], – | – | 1.11[0.51–2.42],.79 | – |
| rs1256049 (C > T) | 97/134/27 | 77/145/42 | 0.57[0.21–1.55],.27 | – | 1.62[0.66–3.96],.29 | – | 0.82[0.43–1.56],.55 | – | |
| rs2077647 (T > G) | 109/107/43 | 97/112/45 | 0.91[0.41–2.05],.82 | – | 1.13[0.53–2.38],.76 | – | 1.01[0.55–1.83], 1.00 | ||
– = not significant, A = minor allele, B = major allele, SNP = single-nucleotide polymorphism.
a
The Bonfferoni correction was applied to correct the P value.