Table 3.
Frequencies of haplotypes (>1%) containing SNPs in ESR1 and ESR2 and association between cases and controls.
| Gene | Haplotypea | Case (freq.) | Control (freq.) | P b | P value (corrected)c | OR [95% CI] |
| ESR1 | ACA | 0.100 | 0.243 | .0005 | .003 | 0.35[0.19–0.65] |
| GCA | 0.214 | 0.085 | .0005 | .003 | 2.99[1.57–5.70] | |
| GCC | 0.041 | 0.054 | .59 | – | 0.76[0.28–2.07] | |
| GTA | 0.385 | 0.334 | .26 | – | 1.28[0.83–2.00] | |
| ESR2 | TTC | 0.064 | 0.060 | .88 | – | 1.07[0.45–2.56] |
| TCC | 0.352 | 0.252 | .04 | .24 | 1.63[1.02–2.59] | |
| TCT | 0.199 | 0.288 | .05 | – | 0.61[0.37–1.01] | |
| GTC | 0.020 | 0.033 | .43 | – | 0.58[0.15–2.56] | |
| GCC | 0.174 | 0.217 | .31 | – | 0.76[0.45–1.29] | |
| GCT | 0.170 | 0.130 | .29 | – | 1.37[0.76–2.49] |
– = not significant, 95% CI = 95% confidence intervals, OR = odds ratio, SNP = single-nucleotide polymorphism.
a
The program, Plink, was used to estimate common (frequency > 0.01) haplotypes constructed by three SNPs of ESR1 (rs9340799, rs2234693, rs3798759) and ESR2 (rs2077647, rs4986938, rs1256049).
b
Each haplotype was compared with the other haplotypes combined.
c
The Bonfferoni correction was applied to correct the P value.