Table 5.
The association between ESR1 and ESR2 polymorphisms and RSA: a meta-analysis.
| Test of association | Test of heterogeneity | |||||||
| Polymorphism | Genotype | Number of studies | OR | 95% CI | P value | Model | P value | I2 (%) |
| ESR1 rs2234693 | Allelic model | 5 | 0.93 | [0.69, 1.26] | .63 | R | .02 | 65 |
| Additive model | 5 | 0.77 | [0.31, 1.90] | .57 | R | .002 | 76 | |
| Dominant model | 5 | 0.88 | [0.53, 1.46] | .61 | R | .005 | 73 | |
| Recessive model | 5 | 1.04 | [0.76, 1.41] | .81 | F | .31 | 17 | |
| ESR1 rs9340799 | Allelic model | 5 | 1.03 | [0.66, 1.60] | .89 | R | .0004 | 81 |
| Additive model | 5 | 1.09 | [0.40, 2.89] | .87 | R | .0008 | 79 | |
| Dominant model | 5 | 1.06 | [0.63, 1.70] | .89 | R | .003 | 75 | |
| Recessive model | 5 | 1.04 | [0.52, 2.11] | .91 | R | .03 | 62 | |
| ESR2 rs1256049 | Allelic model | 5 | 0.97 | [0.65, 1.47] | .90 | R | .04 | 60 |
| Additive model | 5 | 0.52 | [0.20, 1.34] | .18 | R | .10 | 57 | |
| Dominant model | 5 | 1.08 | [0.63, 1.85] | .79 | R | .02 | 65 | |
| Recessive model | 5 | 0.68 | [0.44, 1.05] | .08 | F | .65 | 0 | |
| ESR2 rs4986938 | Allelic model | 5 | 0.89 | [0.74, 1.06] | .18 | F | .26 | 24 |
| Additive model | 5 | 0.49 | [0.21, 0.76] | .002 | F | .33 | 13 | |
| Dominant model | 5 | 1.01 | [0.81, 1.26] | .95 | F | .22 | 30 | |
| Recessive model | 5 | 0.46 | [0.30, 0.69] | .0002 | F | .63 | 0 | |
CI = confidence interval, F = fixed model, OR = odd ratio, R = random model.