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. 2022 Feb 15;135(8):920–929. doi: 10.1097/CM9.0000000000002037

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The expression of hnRNPA1 in CLL and its prognostic value. (A) The transcript level of hnRNPA1 in primary NOTCH1-mutated (n = 7) and NOTCH1-wt (n = 8). CLL samples was detected by qRT-PCR. (B) The protein level of NICD and hnRNPA1 in NOTCH1-mutated (n = 3) and NOTCH1-wt (n = 3) CLL samples was detected by Western blot. (C) Kaplan–Meier curves of TFS (left panel) and OS (right panel) for different mRNA level of hnRNPA1. CLL: Chronic lymphocytic leukemia; hnRNPA1: Heterogeneous nuclear ribonucleoprotein A1; mRNA: Messenger RNA; NICD: NOTCH1 intracellular domain; OS: Overall survival; qRT-PCR: Quantitative real-time polymerase chain reaction; TFS: Treatment-free survival.