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. 2022 Feb 15;135(8):920–929. doi: 10.1097/CM9.0000000000002037

Figure 5.

Figure 5

The relationships between NOTCH1 signaling and hnRNPA1 in CLL. (A) The transcript level of NICD, HES1, and hnRNPA1 in NICD-overexpressed MEC-1 and JVM-3 was tested by qRT-PCR. (B) The protein level of hnRNPA1 in NICD-overexpressed MEC-1 and JVM-3 was tested by Western blot. (C) The transcript level of NOTCH1, HES1, and hnRNPA1 in NOTCH1-knockdown MEC-1 and JVM-3 was tested by qRT-PCR. (D) The protein level of NOTCH1 and hnRNPA1 in NOTCH1-knockdown MEC-1 and JVM-3 was tested by Western blot. CLL: Chronic lymphocytic leukemia; hnRNPA1: Heterogeneous nuclear ribonucleoprotein A1; NICD: NOTCH1 intracellular domain; qRT-PCR: Quantitative real-time polymerase chain reaction.