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. 2022 Feb 15;135(8):920–929. doi: 10.1097/CM9.0000000000002037

Figure 6.

Figure 6

The relationships among NOTCH1, c-Myc, and hnRNPA1 in CLL. (A) The transcript level of c-Myc in primary NOTCH1-mutated (n = 7) and NOTCH1-wt (n = 8) CLL samples was detected by qRT-PCR. (B) The transcript level of c-Myc in NICD-overexpressed and NOTCH1-knockdown MEC-1 as well as JVM-3 detected by qRT-PCR. (C) The protein level of c-Myc in NICD-overexpressed MEC-1 and JVM-3 was tested by Western blot. (D)The protein level of c-Myc and hnRNPA1 after treatment with c-Myc inhibitor 10058-F4 in MEC-1 and JVM-3 tested by Western blot. (E)The protein level of c-Myc and hnRNPA1 after treatment with c-Myc inhibitor 10058-F4 in NICD-overexpressed MEC-1 and JVM-3 tested by Western blot. P < 0.05. CLL: Chronic lymphocytic leukemia; hnRNPA1: Heterogeneous nuclear ribonucleoprotein A1; NICD: NOTCH1 intracellular domain; qRT-PCR: Quantitative real-time polymerase chain reaction.