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. 2022 Jul 11;79(8):410. doi: 10.1007/s00018-022-04429-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Resveratrol treatment restores endothelial function through SIRT1-eNOS axis in mesenteric arteries from Mthfr^+/– mice. A–C Graphs show, from left to right, the ex vivo response of mouse mesenteric arteries obtained from wild-type and Mthfr^+/– mice to endothelium-dependent vasorelaxant acetylcholine (ACh), and endothelium-independent vasorelaxant nitroglycerin (NG) and the dose responses to phenylephrine (PE) (N = 6 for each experiment). D Dose–response curves to acetylcholine (ACh) of mesenteric arteries obtained from Mthfr^+/– mice and their relative littermates in presence of eNOS inhibitor, L-NAME). E Dose–response curves to acetylcholine (ACh) after 1 h of resveratrol (RSV) incubation. F, G Representative western blot analysis of vessels obtained at the end of RSV stimulation and relative quantification. H Dose–response curves to ACh after RSV incubation for 1 h both in presence and absence of SIRT1 inhibitor EX527. *p < 0.05. **p < 0.001; ***p < 0.0001. Statistical analysis was determined by two-way ANOVA followed by Bonferroni’s post hoc test