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. 2022 Apr 27;395(8):945–962. doi: 10.1007/s00210-022-02243-1

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© The Author(s) 2022, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Effect of canagliflozin on ferroptosis and TUNEL analysis. a Representative images of Prussian blue iron staining for HFpEF-treated rat hearts. b, c Immunostaining of 4HNE and TFR1 protein expression in myocardium, followed by the percentages of positive cells in the total cells. d Dead cardiomyocytes measured by TUNEL staining. n = 6 rats/group. Data are presented as mean ± standard deviation. *p < 0.05 versus normal group. #p < 0.05 versus HFpEF group