Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 12;79(8):418. doi: 10.1007/s00018-022-04442-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Structure of CorB and orthologue CNNM2; A Structure of the pentamer Methanoculleus thermophilus Cobalt of resistance CorB MtCorB (PDB: 7M1T) in complex with Mg²⁺-ATP (purple spheres, left panel) with one monomer highlighted. Right panel: zoom in on residues of the CBS domain that bind MgATP. Residues highlighted are homologues to human Cyclin M2 (hCNNM2) associated hypomagnesaemia, seizure, intellectual disability (HSMR) syndrome Thre568Ile (MtCorB-p.Thr313) and hCNNM4 associated Jalili syndrome Arg407Leu (Mt-CorB-p.Arg235). B Schematic depiction of the monomer of CorB (upper panel) and CNNM2 (bottom panel) using same colours as in A to reflect the approximate structure and location. The schematic structure of the human homologue has been depicted, which has been based on the estimated structure using homology modelling of CorB, as illustrated in Chen et al. (2021) [101]