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. Author manuscript; available in PMC: 2023 Jun 8.
Published in final edited form as: Expert Rev Respir Med. 2022 Jun 8;16(5):519–528. doi: 10.1080/17476348.2022.2085091

Figure 2. Classification of DNA methyltransferases (DNMTs) and Methyl-binding Proteins (MBPs).

Figure 2.

A. DNMTs are classified as maintenance or de novo DNA methyltransferases. B. Three major families of MBPs. (i). The MBD family (all with MBD domain), including MeCp2, MBD1, MBD2, and MBD4 preferentially bind methylated DNA. (ii). Kaiso- and Kaiso-like proteins, shown with the main BTB domain and methyl-CpG-binding zinc fingers (mZF). Including Kaiso, ZBTB4, and ZBTB38. (iii). Set and Ring Finger-associated (SRA) domain, two members of UHRF1 and UHRF2 (Ubiquitin-like with PHD and RING finger domains 1 and 2). Ubl, ubiquitin-like domain; TTD, tandem tudor domain; PHD, plant homeodomain finger domain; SRA, SET, and RING-associated domain.