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. 2022 Jul 12;8:81. doi: 10.1038/s41523-022-00444-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Whisker box plots of expression signature scores comparing DEGs of duct- (left) and TDLU-derived (right) luminal cells with gene expression profiles of different breast cancer subtypes (basal-like (Basal), normal-like (Normal), Claudin^low (Claudin low), HER2-enriched (Her2), luminal type B (LumB), and luminal type A (LumA)). Boxes represent median ± quantiles. Whiskers indicate the minimum and maximum values. **p < 0.01 by Kruskal–Wallis test with Dunn’s multiple comparisons test. b Whisker box plot showing KRT15 gene expression in the different breast cancer subtypes. KRT15 is significantly upregulated in basal-like breast cancer compared to the other breast cancer subtypes (n = 2164, GENT2 database). Boxes represent median ± quantiles. Whiskers indicate the minimum and maximum values. ****p < 0.001 by one-way ANOVA with Tukey’s multiple comparison test. Source data are provided as a Source Data file. c Representative fluorescence multicolor imaging of cryostat sections of basal-like breast carcinomas stained for K15 (red), K14 (green), and nuclei (blue). Nine out of 36 basal-like breast carcinomas stained positive for both K15 and K14. Scale bar = 50 μm.