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. 2022 Jul 11;13(7):593. doi: 10.1038/s41419-022-05026-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The 3D profile according to the fold-change values of differentially expressed genes. B KEGG pathway analysis of common terms revealed enrichment of genes related to various events. C, D Differential expression of FN1 and CHD4 in GC cells treated with 1 μg/ml LSECtin protein (12 h, 18 h, and 24 h) were detected by Western blot (C) and qPCR (D), with controls treated with isotype IgG for 24 h. E Survival analysis of GC patients based on FN1 and CHD4 expression were analyzed by Kaplan-Meier plotter database. F FN1 and CHD4 expression levels in 415 samples of gasric cancer and 35 samples of normal tissue, FN1 and CHD4 expression levels in 32 tumor and matched normal samples from GC patients, G Venn diagram showing the transcription factors that coregulated FN1 and CHD4 identified in two databases. H, I The expression of FN1 and CHD4 in GC cells after STAT1 knockdown, or overexpression were analyzed by qPCR (H) and Western blot analysis (I). J Schematic representation of the STAT1-binding site in the FN1 and CHD4 promoters. Chromatin immunoprecipitation (ChIP) assays confirming FN1 and CHD4 promoter region enrichment with and anti-STAT1 antibody. K Western blot analysis of FN1 and CHD4 expression after the knockdown or overexpression of STAT1 in BGC-823 cells and LSECtin-induced. Error bars indicate standard deviation (n = 3). Data, the means ± SD.