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. 2022 Jul 11;13(7):593. doi: 10.1038/s41419-022-05026-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A LSECtin promoted the expression of miR-146a-5p in GC cells. B LSECtin inhibited the expression of hsa_circ_0077417 in GC cells. C Western blot experiments showed that LSECtin and miR-146a-5p coregulate STAT1 expression in GC cells. D Western blot experiments showed that LSECtin and circFBXL4 coregulate STAT1 expression in GC cells. E Western blot experiments showed that LSECtin upregulate FN1/CHD4 expression via the circFBXL4/miR-146a-5p axis. F Cell viability in different groups was detected by EdU assays, and the statistical analysis of EdU staining. G The migration of BGC-823 cells in different groups was detected by wound healing assays. H Transwell migration and invasion assays were performed to analyze the migration and invasion abilities of GC cells. I Adhesion between GC cells and frozen mouse lymph node sections in vitro was detected by H&E staining (left), The right panel shows the number of analysis of cells. J LSECtin expressed in lymph nodes of nude mice affected the expression of circFBXL4, miR-146a-5p and STAT1 in gastric cancer cells. K The expression of circFBXL4, miR-146a-5p and STAT1 in lymph nodes was correlated with statistical significance. Error bars indicate standard deviation (n = 3). Data, the means ± SD.