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. 2022 Jul 12;12:11823. doi: 10.1038/s41598-022-14686-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of selection signals around TBX19 gene locus in XPs, and three putative functional variants (p.N105T, p.M158V, p.T189A). (a) The Fst and θπ values around the TBX19 locus. (b) Cross-species alignment of the protein sequences around three functional variants (p.N105T, p.M158V, p.T189A) in TBX19 gene. The dots in the alignment indicated the amino acids which were identical with those in XPs, and the dashes indicated the missing data. (c) Distribution of the allele frequency of the three variants in three populations (XP, DU, and LW).