Table 1.
Clinical data and OCT/OCT-A parameters.
| Control | Glaucoma | P-Value | |
|---|---|---|---|
| Clinical data | |||
| Eye (n) | OD:19|OS:11 | OD:30|OS:38 | 0.131 |
| Glaucoma entity (n) | POAG:0|XFG:0|NTG:0|PG:0|ACG:0 | POAG:49|XFG:9|NTG:5|PG:2|ACG:3 | n.a |
| 1st diagnos. of glaucoma (Mo) | 72.00 [29.75–120.00] | n.a | |
| Age at OP | 66.77 ± 9.01 | 64.51 ± 12.18 | 0.372 |
| Sex (n) | Female:20|Male:10 | Female:41|Male:27 | 0.711 |
| IOP (mmHg) | 14.00 [12.00–14.00] | 18.00 [15.00–21.25] | < 0.0013 |
| Refractive error (dpt) | 0.07 ± 2.88 | 0.00 [-1.38–0.50] | 0.293 |
| Visual acuity (LogMAR) | 0.40 [0.30–0.60] | 0.12 [0.00–0.30] | < 0.0013 |
| Previous surgeries (n) |
Cataract:10 Laser trabeculoplasty:4 Laser iridotomy:3 |
n.a | |
| MAP (mmHg) | 95.00 [92.50–99.50] | 93.33 [91.67–101.67] | 0.763 |
| Topical antiglaucomatosa | 3.00 [2.00–4.00] | n.a | |
| Beta n (%) | 43 (74.1%) | n.a | |
| CAI n (%) | 47 (81.0%) | n.a | |
| PGA n (%) | 51 (87.9%) | n.a | |
| Alpha n (%) | 23 (39.7%) | n.a | |
| Pilo n (%) | 2 (3.4%) | n.a | |
| Systemic CAI n (%) | 5 (8.6%) | n.a | |
| OCT and OCT-A parameter | |||
| Ganglion cell complex (µm) | 96.55 ± 8.41 | 76.00 [67.00–84.00] | < 0.0013 |
| Focal loss volume (%) | 0.41 [0.21–0.80] | 5.67 [2.42–9.59] | < 0.0013 |
| Global loss volume (%) | 2.10 [0.50–4.25] | 19.24 ± 10.91 | < 0.0013 |
| RNFL thickness (µm) | 96.79 ± 8.72 | 72.72 ± 13.10 | < 0.0012 |
| Cup/disc ratio total | 0.31 ± 0.15 | 0.68 [0.58–0.77] | < 0.0013 |
| Rim area (mm2) | 1.37 ± 0.35 | 0.68 [0.49–0.91] | < 0.0013 |
| Disc area (mm2) | 2.03 ± 0.32 | 2.05 ± 0.34 | 0.782 |
| VD ONH whole | 47.00 ± 2.52 | 35.40 [30.17–38.90] | < 0.0013 |
| VD macula SVP whole | 41.90 ± 4.15 | 37.02 ± 4.28 | < 0.0012 |
| VD fovea SVP | 19.99 ± 6.69 | 17.30 [11.12–21.65] | 0.063 |
| VD macula DVP whole | 39.96 ± 4.37 | 41.90 ± 4.83 | 0.062 |
| VD fovea DVP | 34.28 ± 8.49 | 32.23 ± 7.99 | 0.262 |
| FAZ | 0.26 ± 0.10 | 0.26 [0.22–0.38] | 0.293 |
n.a. not applicable, POAG primary open-angle glaucoma, XFG exfoliative glaucoma, NTG normal-tension glaucoma, PG pigmentary glaucoma, ACG angle-closure glaucoma, MAP mean arterial pressure, Beta beta-blocker, CAI carbonic anhydrase inhibitor, PGA prostaglandin analogue, Alpha alpha-adrenergic agonist, Pilo pilocarpine, RNFL retinal nerve fiber layer, ONH optic nerve head, VD vessel density, FAZ foveal avascular zone, SVP superficial vascular plexus, DVP deep vascular plexus.
*p < 0.05.
1 Chi-square-test.
2t-test.
3Wilcoxon rank sum test.