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. 2022 Jul 11;13(7):597. doi: 10.1038/s41419-022-05040-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A UCSC predicted two types of snoRNA (SNORD104 and SNORA50C) derived from SNHG25 gene. B RT-qPCR detected SNORD104 and SNORA50C expression in SNHG25-depleted SK-N-AS and SK-N-SH cells. (Student’s t-test) C The transfection efficiency of the SNHG5 overexpression vector was detected in SK-N-AS and SK-N-SH cells by RT-qPCR. (Student’s t-test) D RT-qPCR detected SNORA50C expression in SK-N-AS and SK-N-SH cells with SNHG25 upregulation. (Student’s t-test) E SNORA50C expression was analyzed in NBL tissues and normal neural tissues from the combined cohort of TCGA TARGET GTEx in UCSC-XENA. F The expression correlation of SNHG25 with SNORA50C in NB cells was obtained from GSE89413 dataset. G SNORA50C expression in NB cells, MCF-10A cells, and HEK-293T cells were detected by RT-qPCR. (One-way ANOVA, Tukey) H The interference efficiency of SNORA50C ASO was detected in SK-N-AS and SK-N-SH cells by RT-qPCR. (Student’s t-test) I RT-qPCR detected SNHG25 expression in SK-N-AS and SK-N-SH cells with SNORA50C silence. (Student’s t-test) J The overexpression efficiency of SNORA50C was detected in SK-N-AS and SK-N-SH cells by RT-qPCR. (Student’s t-test) K RT-qPCR detected SNHG25 expression in SK-N-AS and SK-N-SH cells with SNORA50C elevation. (Student’s t-test) ^**P < 0.01. Error bars indicate mean ± SD. (N = 3).