Table 5.

Histomorphometric analysis on alveolar sockets grafted with CBXs for ARP. Data are presented as Mean percentages ± SD

Reference	Untreated group	Treated group 1 (ARP)	Treated group 2 (ARP)	Description of the endpoint	Histomorphometric outcomes Untreated group	Histomorphometric outcomes Treated group 1	Histomorphometric outcomes Treated group 2
Barone et al., 2008	Extraction alone	CBX covered by a collagen membrane	-	Total bone volume	25.7 ± 9.5%	35.5 ± 10.4%*	-
				Connective tissue	59.1 ± 10.4%	36.6 ± 12.6%*	-
				Residual graft material	-	29.2 ± 10.1%	-
Timepoint of analyses: 7 months
Barone et al., 2015	-	CBX covered by a collagen membrane and added with a full thickness mucoperiosteal flap and primary soft tissue closure	CBX covered by a collagen membrane with a flapless procedure and a secondary soft tissue closure	Newly formed bone	-	22.5 ± 3.9%	22.5 ± 4.3%
				Marrow spaces	-	59.3 ± 7.5%	59.4 ± 6.8%
				Residual graft material	-	18.2 ± 6.1%	18.2 ± 5.2%
Timepoint of analyses: 3 months
Barone et al., 2017	Spontaneous healing	Collagenated CBX covered by a collagen membrane	ABX covered by a collagen membrane	Newly formed bone	44.0 ± 14.7%	41.4 ± 20.6%	36.8 ± 19.1%
				Non-mineralized tissues	56.0 ± 14.7%	41.4 ± 15.9%*	47.8 ± 19.2%
				Residual graft particles	-	14.9% ± 7.3%	15.5 ± 8.4%
Timepoint of analyses: 3 months
Di Stefano et al., 2019a	-	CBX covered by a collagen membrane	ABX covered by a collagen membrane	Newly formed bone	-	45.12 ± 10.54%**	33.61 ± 9.71%
				Residual biomaterial	-	10.91 ± 4.27%**	18.47 ± 5.62%
Timepoint of analyses: 4–8 months

Abbreviations: ABX Anorganic bone xenograft, CBX Collagen-preserving bone xenograft

^*Significantly different from the untreated group (p < 0.05)

^**Significantly different from the treated group 2 (p < 0.05)