Table 2.
Differences in myocardial glucose metabolic rate and insulin sensitivity of subjects with T2DM according to metabolic syndrome compared to control subjects.
|
Control group (n = 10) |
T2DM | Control vs. T2DM non-MetS | Control vs. T2DM MetS | T2DM Non-MetS vs. T2DM MetS | |||||
|---|---|---|---|---|---|---|---|---|---|
|
Non-MetS (n = 6) |
MetS (n = 19) |
P-value | P-value§ | P-value | P-value§ | P-value | P-value§ | ||
| Insulin-stimulated glucose disposal (mg/min x Kg FFM) | 13.01 ± 8.53 | 2.91 ± 1.54 | 3.06 ± 1.7 | <0.0001 | 0.01 | <0.0001 | 0.008 | 0.6 | – |
| Myocardial MRGlu (μmol/min/100 g) | 32.9 ± 9.7 | 25.15 ± 4.92 | 10.5 ± 9.04 | 0.04 | 0.03 | <0.0001 | <0.0001 | 0.001 | 0.01 |
| LAD Myocardial MRGlu (μmol/min/100 g) | 32.41 ± 8.79 | 23.2 ± 5.6 | 10.03 ± 9.6 | 0.04 | 0.02 | <0.0001 | <0.0001 | 0.003 | 0.04 |
| RCA Myocardial MRGlu (μmol/min/100 g) | 33.69 ± 12.38 | 26.59 ± 4.7 | 9.9 ± 8.00 | 0.05 | 0.04 | <0.0001 | <0.0001 | 0.002 | 0.001 |
| LCX Myocardial MRGlu (μmol/min/100 g) | 32.79 ± 9.1 | 26.3 ± 5.7 | 11.7 ± 9.6 | 0.05 | 0.04 | <0.0001 | <0.0001 | 0.002 | 0.02 |
Continous data are expressed as means ± SD. Comparisons between the groups were performed using a general linear model. MRGlu, glucose metabolic rate; LAD, left anterior descending; LCX, left circumflex; RCA, right coronary artery. §P-values refer to results after analyses with adjustment for age and gender.