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. 2022 Jun 29;13:910308. doi: 10.3389/fphar.2022.910308

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Copyright © 2022 Yang, Zhang, Yang, Ding and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low-dose RSV evidently reduced hair cell loss during the progression of ARHL. (A,B) The SEM of OC in different groups (Yang group, Old group, RSV 50 mg/kg group, RSV 100 mg/kg group and RSV 300 mg/kg group); Scale bar = 30 μm/3 μm; In the Old group, the RSV 100 mg/kg and the RSV 300 mg/kg groups, the V-shape of cells were disappeared, the arrangement were disordered and lodging and the number was decreased evidently. While in young and RSV 50 mg/kg, stereocilia bundles show a V-shape, neatly arranged and slightly absent; RSV, resveratrol; OHCs, outer hair cells; OC, organ of Corti.