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. 2022 Jun 29;13:910308. doi: 10.3389/fphar.2022.910308

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Copyright © 2022 Yang, Zhang, Yang, Ding and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low-dose RSV evidently inhibited RIPK3-mediated necroptosis in aging cochlea. The expression of RIPK3, RIPK1, and MLKL at different locations (OC and SGN) in RSV 50 mg/kg, RSV 100 mg/kg and RSV 300 mg/kg groups was detected by immunofluorescence; RSV, resveratrol; RIPK3, receptor-interacting serine/threonine protein kinase 3; RIPK1, receptor-interacting serine/threonine protein kinase 1; MLKL, mixed lineage kinase domain-like protein; OC, organ of Corti; SGN, spiral ganglion neuron. Scale bar = 25 μm.