Table 1.
The characteristics of the included animal studies.
| Dietary nutrients | Studies | Country | Randomization | Animals | Intervention | Comparison | Outcomes | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Species | Tumor-bearing | Chemotherapeutic agents | Food intake | Main ingredients | Duration | Sample size | Grouping | Control groups | Treated groups | |||||
| Polyphenols | Adiyaman et al. (38) | Turkey | Not reported | Rats, sprague dawley | Healthy | DOX | Grape seed extract | Proanthocyanidin | 35 days | 28 | 4 | (1) CON (2) grape seed extract (3) DOX |
(4) DOX+grape seed extract | b, c, d |
| Ammar et al. (39) | Egypt | Not reported | Rats, sprague dawley | Healthy | DOX | Proanthocyanidin | Proanthocyanidin | 10 days | 24 | 4 | (1) CON (2) proanthocyanidin (3) DOX |
(4) DOX+proanthocyanidin | b, c, e | |
| Boghdady (40) | Egypt | Yes | Rats, wistar albino | Healthy | DOX | Grape seed extract | Proanthocyanidin | 15 days | 32 | 4 | (1) CON (2) DOX |
(3) DOX+grape seed extract (4) DOX+ginkgo biloba extract |
b, c, d | |
| Yalcin et al. (41) | Turkey | Yes | Mice, albino | Healthy | DOX | Grape seed extract | Proanthocyanidin | 21 days | 36 | 6 | (1) CON (2) DOX (3) grape seed extract 50 (4) grape seed extract 150 |
(5) DOX+grape seed extract 50 (6) DOX+grape seed extract 150 |
c, d | |
| Yousef et al. (42) | Egypt | Not reported | Rats, sprague dawley | Healthy | Cisplatin | Grape seed extract | Proanthocyanidin | 15 days | 32 | 4 | (1) CON (2) grape seed extract (3) cisplatin |
(4) cisplatin+grape seed extract | b, c, f | |
| Zhang et al. (43) | China | Yes | Mice, balb/c | Sarcoma | DOX | Proanthocyanidin | Proanthocyanidin | 10 days | 56 | 4 | (1) CON (2) DOX (3) proanthocyanidin |
(4) DOX+proanthocyanidin | b, c | |
| Petroni et al. (44) | Italy | Not reported | Mice, c57bl/6j | Healthy | DOX | Cyanidin 3-glucoside | Anthocyanin | 74 days | 24 | 2 | (1) DOX+yellow diet | (2) DOX+red diet | f | |
| Shoukry et al. (45) | Egypt | Yes | Rats, wister | Healthy | DOX | Resveratrol | Resveratrol | 42 days | 32 | 4 | (1) CON (2) DOX |
(3) DOX+resveratrol(pre) (4) DOX+resveratrol(post) |
a, b, d, f | |
| Arafa et al. (46) | Egypt | Not reported | Rats, wistar albino | Healthy | DOX | Resveratrol | Resveratrol | 28 days | 40 | 4 | (1) CON (2) resveratrol (3) DOX |
(4) DOX+resveratrol | b, c, d, f | |
| Ibrahim Fouad and Ahmed. (47) | Egypt | Yes | Rats, wistar albino | Healthy | DOX | Curcumin | Curcumin | / | 24 | 4 | (1) CON (2) DOX (3) curcumin |
(4) DOX+curcumin | b, c | |
| Bahadir et al. (48) | Turkey | Yes | Rats, wistar albino | Healthy | Cisplatin | Curcumin | Curcumin | 14 days | 49 | 7 | (1) CON (2) placebo (3) cisplatin (4) beta-carotene (6) curcumin |
(5) cisplatin+beta-carotene (7) cisplatin+curcumin |
b, c, d | |
| Benzer et al. (49) | Turkey | Yes | Rats, wistar albino | Healthy | DOX | Curcumin | Curcumin | 7 days | 35 | 5 | (1) CON (2) curcumin 200 (3) DOX |
(4) DOX+curcumin 100 (5) DOX+curcumin 200 |
b, c, d | |
| Swamy et al. (50) | India | Yes | Rats, albino | Healthy | DOX | Curcumin | Curcumin | 14 days | 24 | 4 | (1) CON (2) DOX (3) curcumin |
(4) DOX+curcumin | b, c, d, f | |
| Venkatesan (51) | India | Not reported | Rats, wistar | Healthy | DOX | Curcumin | Curcumin | 7 days | 24 | 4 | (1) CON (2) curcumin (3) DOX |
(4) DOX+curcumin | b, c, e | |
| Ibrahim et al. (52) | Saudi Arabia | Yes | Mice, balb/c | Healthy | Cisplatin | Green tea extract, vitamin E | Catechins, vitamin E | 30 days | 48 | 6 | (1) CON (2) green tea extract (3) vitamin E (4) cisplatin |
(5) cisplatin+green tea extract (6) cisplatin+vitamin E |
b, c, f | |
| Saeed et al. (53) | Egypt | Yes | Rats, wistar | Healthy | DOX | Epigallocatechin-3-gallate | Catechins | 12 days | 40 | 5 | (1) CON (2) DOX |
(3) DOX+epigallocatechin-3-gallate 10 (4) DOX+epigallocatechin-3-gallate 20 (5) DOX+epigallocatechin-3-gallate 40 |
b, c, d, e | |
| Amanullah et al. (54) | India | Not reported | Rats, wistar albino | Healthy | DOX | Black tea extract, resveratrol | Catechins, polyphenols | 30 days | 30 | 6 | (1) CON (2) DOX (3) black tea extract+ resveratrol |
(4) DOX+black tea extract (5) DOX+resveratrol (6) DOX+black tea extract +resveratrol |
b, c, f | |
| Mubarak et al. (55) | Egypt | Not reported | Rats, albino | Healthy | DOX | Date palm fruit extract | Anthocyanins, quercetin, procyanidins | 30 days | 40 | 4 | (1) CON (2) date (3) DOX |
(4) DOX+date | b, c | |
| Sabbah et al. (56) | Saudi Arabia | Yes | Rats, wistar albino | Healthy | DOX | Ajwa date aqueous extract | Polyphenols, flavonoids, Mn | 28 days | 60 | 6 | (1) CON (2) date 0.75 (3) date 1.5 (4) DOX |
(5) DOX+date 0.75 (6) DOX+date 1.5 |
b, c, d | |
| Ribeiro et al. (57) | Brazil | Not reported | Rats, wistar | Healthy | DOX | Pera orange juice, Moro orange juice | Hesperidin, anthocyanins | 28 days | 120 | 6 | (1) CON (2) Pera juice (3) Moro juice (4) DOX |
(5) DOX+Pera juice (6) DOX+Moro juice |
a, c, f | |
| Elberry et al. (58) | Saudi Arabia | Yes | Rats, wister | Healthy | DOX | Cranberry extract | Flavonols, flavonoids | 10 days | 30 | 4 | (1) CON (2) cranberry extract (4) DOX |
(4) DOX+cranberry extract | b, c, e | |
| Abu Gazia and El-Magd (59) | Egypt | Yes | Rats, albino | Healthy | DOX | Cardamom extract | Flavonoids | 21 days | 30 | 3 | (1) CON (2) DOX |
(3) DOX+cardamom extract | b, c, d | |
| Hassanpour Fard et al. (60) | India | Not reported | Rats, wistar albino | Healthy | DOX | Whole fruit extract of pomegranate | Gallic acid, quercetin | 18 days | 24 | 3 | (1) CON (2) DOX |
(3) DOX+pomegranate extract | b, c, d, e, f | |
| Shatoor and Said Ahmed, (61) | Saudi Arabia | Yes | Rats, wistar albino | Healthy | DOX | Hawthorn extrat | Flavonoids, polyphenols | 28 days | 36 | 6 | (1) CON (2) hawthorn (3) DOX |
(4) DOX+hawthorn(st) (5) DOX+hawthorn(post) (6) hawthorn+DOX(pre) |
b, c, d, f | |
| Subburaman et al. (62) | India | Not reported | Rats, albino | Healthy | DOX | Naringenin | Flavonoids | 70 days | 18 | 3 | (1) CON (2) DOX |
(3) DOX+naringenin | b, c, d, f | |
| Abdel-Wahab et al. (63) | Egypt | Not reported | Rats, swiss albino | Healthy | DOX | P-coumaric acid | p-coumaric acid (pca) | 5 days | 24 | 4 | (1) CON (2) P-coumaric acid (3) DOX |
(4) DOX+p-coumaric acid | b, c | |
| Alhumaydhi (64) | Saudi Arabia | Yes | Mice, balb/c | Healthy | DOX | Honey | Polyphenols, fructose, glucose | 10 days | 40 | 4 | (1) CON (2) honey (3) DOX |
(4) DOX+honey | b | |
| Abu-Elsaad et al. (65) | Egypt | Not reported | Rats, sprague dawley | Healthy | DOX | Tested food: yogurt, green tea extract, carrot | Lactobacillus acidophilus, polyphenols, carrot | 154 days | 60 | 5 | (1) CON (2) DOX (3) DOX+carvedilol |
(4) DOX+tested food (5) DOX+tested food+carvedilol |
b, c, d, e | |
| Lin et al. (66) | China | Yes | Rats, sprague dawley | Healthy | DOX | Yellow wine polyphenolic compounds | Polyphenolic compounds | 28 days | 50 | 5 | (1) CON (2) yellow wine (3) DOX |
(4) DOX+yellow wine | a, c, d, e, f | |
| Allicin | Abdel-Daim et al. (67) | Egypt | Yes | Mice, swiss albino | Healthy | DOX | Allicin | Allicin | 14 days | 40 | 5 | (1) CON (2) allicin 20 (3) DOX |
(4) DOX+allicin 10 (5) DOX+allicin 20 |
b, c |
| Demirkaya et al. (68) | Turkey | Yes | Rats,wistar albino | Healthy | DOX | Aged garlic extract, grape seed extract, hazelnut | Allicin, proanthocyanidin | 42 days | 135 | 9 | (1) CON (2) DOX 15 (3) DOX 7.5 |
(4) DOX 15+aged garlic extract (5) DOX 7.5+aged garlic extract (6) DOX 15+grape seed extract (7) DOX 7.5+grape seed extract (8) DOX 15+ hazelnut (9) DOX 7.5+hazelnut |
b, c, d | |
| Mukherjee et al. (69) | India | Not reported | Rats, wistar albino | Healthy | DOX | Garlic homogenate | Allicin | 30 days | 40 | 5 | (1) CON (2) DOX (3) DOX+PRO |
(4) DOX+garlic 250 (5) DOX+garlic 500 |
c, f | |
| Lycopene | Ferreira et al. (70) | Brazil | Not reported | Rats, wistar | Healthy | DOX | Tomato-oleoresin supplement | Lycopene | 49 days | 34 | 4 | (1) CON (2) lycopene (3) DOX |
(4) DOX+lycopene | d |
| Yilmaz et al. (71) | Turkey | Not reported | Rats, sprague dawley | Healthy | DOX | Lycopene | Lycopene | 10 days | 24 | 4 | (1) CON (2) DOX |
(3) DOX+lycopene(pre) (4) DOX+lycopene(post) |
c, d | |
| PUFA | Ahmed et al. (72) | India | Yes | Rats, wistar | Healthy | DOX | Chia seed oil | PUFA | 7 days | 24 | 4 | (1) CON (2) DOX |
(3) DOX+chia seed oil 2.5 (4) DOX+chia seed oil 5 |
b, c, d, e |
| Asselin et al. (73) | Canada | Yes | Mice, c57bl/6 | Healthy | DOX+TRZ | Flaxseed, α-linolenic acid, secoisolariciresinol diglucoside | α-Linolenic acid, secoisolariciresinol diglucoside | 42 days | 84 | 5 | (1) CON (2) DOX+TRZ |
(3) DOX+TRZ+flaxseed (4) DOX+TRZ+α-linolenic acid (5) DOX+TRZ+secoisolariciresinol diglucoside |
a, d, e | |
| Saleh et al. (74) | Egypt | Not reported | Rats, wistar albino | Healthy | DOX | N-3 PUFA | n-3 PUFA | 28 days | 35-40 | 5 | (1) CON (2) DOX |
(3) DOX+n-3 PUFA 25 (4) DOX+n-3 PUFA 50 (5) DOX+n-3 PUFA100 |
b, c, d, e, f | |
| Saleem et al. (75) | India | Not reported | Rats, wistar albino | Healthy | DOX | Sesame oil | Linoleic acid, α-linolenic acid, sesamin | 30 days | 30 | 5 | (1) CON (2) DOX (5) DOX+probucol |
(3) DOX+sesame oil 1 (4) DOX+sesame oil 2 |
b, c, d | |
| Teng et al. (76) | China | Yes | Rats, sprague dawley | Healthy | DOX | N-3 PUFA | Timnodonic acid, docosahexaenoic acid | 112 days | 32 | 3 | (1) CON (2) DOX |
(3) DOX+n-3 PUFA | a, d | |
| Amino acids |
Maneikyte et al. (77) | Austria | Yes | Rats, wag/rij | Colorectal cancer liver metastasis | FOLFOX | Glycine | Glycine | 21 days | 44 | 6 | (1) casein+sham (2) glycine+sham (3) casein+CON (5) casein+FOLFOX |
(4) glycine+CON (6) glycine+FOLFOX |
a, b, d |
| Todorova et al. (78) | USA | Yes | Rats, fisher344 | Mammary carcinoma | DOX | Glutamine | Glutamine | / | 50 | 3 | (1) CON (2) DOX+water |
(3) DOX+glutamine | a, b | |
| Todorova et al. (79) | USA | Yes | Rats, fisher344 | Mammary carcinoma | DOX | Glutamine | Glutamine | 7 days | 20 | 2 | (1) DOX+CON | (2) DOX+glutamine | a, c | |
| Cao et al. (80) | USA | Yes | Rats, fisher 344 | Healthy | DOX | Glutamine | Glutamine | 28 days | 42 | 6 | (1) H2O+saline (2) H2O+DOX |
(3) glutamine+saline (4) glutamine+DOX |
c | |
| CoQ10 | Rahmanifard et al. (81) | Iran | Yes | Rats, sprague dawley | Healthy | DOX | CoQ10 | CoQ10 | 21 days | 42 | 6 | (1) CON (2) lisinopril (3) CoQ10 (4) DOX |
(5) DOX+lisinopril (6) DOX+CoQ10 |
c, d, e, f |
| Shabaan et al. (82) | Egypt | Yes | Rats, wistar | Healthy | DOX | CoQ10 | CoQ10 | 7 days | 28 | 4 | (1) CON (2) CoQ10 (3) DOX |
(4) DOX+CoQ10 | c, d | |
| Botelho et al. (83) | Brazil | Yes | Rats, wistar albino | Healthy | DOX | CoQ10 | CoQ10 | 14 days | 20 | 4 | (1) CON (2) CoQ10 (3) DOX |
(4) DOX+CoQ10 | b, c, d, e | |
| Chen et al. (84) | China | Yes | Rats, sprague dawley | Healthy | DOX | CoQ10 | CoQ10 | 21 days | 24 | 4 | (1) CON (2) DOX (4) CoQ10 |
(3) DOX+CoQ10 | d, f | |
| Mustafa et al. (85) | Saudi Arabia | Not reported | Rats, wistar albino | Healthy | DOX | CoQ10 | CoQ10 | 15 days | 72 | 6 | (1) CON (2) DOX (3) CoQ10 |
(4) DOX+CoQ10 | b, c, e, f | |
| Trace elements | Maryoosh et al. (86) | Iraq | Yes | Rats, wistar albino | Healthy | mitoxantrone | Zinc sulfate | Zinc | 20 days | 48 | 6 | (1) CON (2) Zinc 15 (3) Zinc 30 (4) mitoxantrone |
(5) mitoxantrone+Zinc 15 (6) mitoxantrone+Zinc 30 |
b, c |
| Wu et al. (87) | China | Yes | Rats, sprague dawley | Healthy | DOX | ZnCM | Zinc, curcumin | 28 days | 42 | 6 | (1) CON (2) DOX |
(3) DOX+curcumin 100 (4) DOX+ZnCM 25 (5) DOX+ZnCM 50 (6) DOX+ZnCM 100 |
a, b, e | |
| Coudray et al. (88) | France | Not reported | Rats, wistar | Healthy | DOX | Selenium | Selenium | 49 days | 60 | 5 | (1) CON (2) saline (3) DOX (4) selenium |
(5) DOX+selenium | c, f | |
| Others | Radeva-Ilieva et al. (89) | Bulgaria | Yes | Rats, wistar | Healthy | DOX | Methylxanthine from bancha | Methylxanthine | 17 days | 36 | 6 | (1) CON (2) DOX (3) methylxanthine 5 (4) methylxanthine 1 |
(5) DOX+methylxanthine 5 (6) DOX+methylxanthine 1 |
b |
| Wahab et al. (90) | Egypt | Yes | Mice, swiss albino | Ehrlich ascites carcinoma | DOX | Vitamin E | Vitamin E | 30 days | 140 | 4 | (1) DOX | (2) DOX+vitamin E | c | |
CON, control; CoQ10, coenzyme Q10; DOX, doxorubicin; FOLFOX, 5-fluorouracil+leucovorin+oxaliplatin; PUFA, polyunsaturated fatty acids; TRZ, trastuzumab; ZnCM, zinc+curcumin.
a, echocardiography; b, serum cardiac markers; c, oxidative stress markers; d, histopathological examinations; e, electrocardiogram; f, survival, body weight, heart weight.