Table 2.

The characteristics of the included human studies.

Dietary nutrients	Studies	Country	Study design	Participants				Intervention			Comparison				Outcomes
				Cancer type	Gender	Age	Chemotherapeutic agents	Food intake	Main ingredients	Duration	Sample size	Grouping	Control groups	Treated groups
PUFA	El Amrousy et al. (91)	Egypt	RCT	Acute lymphoblastic leukemia	Male, 36 Female, 24	8.7 ± 1.9 years old	DOX	Omega 3 fatty acids	Omega 3 fatty acids	180 days	60	2	(1) DOX	(2) DOX+omega 3 fatty acids	a, b, c
	Hagag et al. (92)	Egypt	RCT	Acute lymphoblastic leukemia	Male, 25 Female, 15	2-16 years old	DOX	Black seed oil	PUFA (linoleic acid, oleic acid, palmitic acid)	7 days	40	2	(1) DOX+placebo	(2) DOX+black seed oil	a
CoQ10	Iarussi et al. (93)	Italy	Non-randomized controlled trial	Acute lymphoblastic leukemia, non-hodgkin lymphoma	/	1-15 years old	Anthracyclines	CoQ10	CoQ10	/	20	2	(1) anthracyclines	(2) anthracyclines+CoQ10	a
	Cortes et al. (94)	USA	Non-randomized controlled trial	Bronchogenic carcinoma, other carcinoma	Male, 11 Female, 7	56.87 years old	DOX	CoQ10	CoQ10	150 days	18	2	(1) DOX	(2) DOX+CoQ10	a, d

CON, control; CoQ10, coenzyme Q10; DOX, doxorubicin; PUFA, polyunsaturated fatty acids; RCT, randomized controlled trial.

a: echocardiography; b: serum cardiac markers; c: oxidative stress markers; d: electrocardiograph.