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. 2022 Jul 6;11(7):bio059290. doi: 10.1242/bio.059290

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Phenotyping of the VDR null rat. (A) No VDR protein was detected by western blot in the colon of VDR^−/− rats. (B) On an ND, VDR^−/− rats show a significant reduction in serum calcium within 2 weeks, which is further reduced by 4 weeks on diet (P<0.0001). Feeding knockout rats RD maintains their serum calcium at normal levels comparable to wild-type animals on either diet. (C) As expected, serum PTH was significantly elevated in VDR^−/− rats maintained on ND (P<0.001); this increase was generally abrogated when VDR^−/− rats were placed on RD. Black bars, VDR^+/+ on RD (n=6); gray bars, VDR^+/+ on ND (n=6); white bars, VDR^−/− on RD (n=7); hatched bars, VDR^−/− on ND (n=7). Serum biochemical assay results were analyzed using a two-sided Wilcoxon rank sum test. * P≤0.05, ns denotes no statistically significant difference. Data shown as mean±s.d.