Table 3.
Nominal multinomial model estimates of odds of trajectory group membership by baseline demographic characteristics, baseline health status, or year-8 health status
| Gain vs. stable | Steady loss vs. stable | Steep loss vs. stable | P | |
|---|---|---|---|---|
| Baseline demographic characteristics | ||||
| Randomization group, ILI vs. DSE | 1.06 (0.83, 1.36) | 0.70 (0.61, 0.80) | 0.66 (0.53, 0.82) | <0.0001 |
| Age, 5-year increase | 0.86 (0.78, 0.94) | 1.09 (1.03, 1.14) | 1.21 (1.11, 1.31) | <0.0001 |
| BMI, 5 kg/m2 unit | 1.10 (0.99, 1.23) | 1.06 (1.00, 1.13) | 1.36 (1.24, 1.49) | <0.0001 |
| Diabetes duration, 5 years | 1.02 (0.93, 1.13) | 1.04 (0.99, 1.10) | 1.20 (1.11, 1.29) | 0.0001 |
| Baseline health status adjusted for baseline demographic characteristics | ||||
| Insulin, yes vs. no | 1.06 (0.72, 1.57) | 0.96 (0.77, 1.20) | 1.16 (0.83, 1.62) | 0.7278 |
| Frailty index, ≥0.21 vs. <0.21 | 1.08 (0.83, 1.42) | 1.03 (0.88, 1.19) | 0.98 (0.77, 1.26) | 0.9313 |
| Multimorbidity index, ≥2 vs. 0–1 | 1.61 (1.17, 2.21) | 1.14 (0.96, 1.34) | 1.62 (1.17, 2.23) | 0.0018 |
| Depressive symptoms, ≥10 vs. <10 | 1.08 (0.78, 1.50) | 1.13 (0.93, 1.36) | 1.17 (0.86, 1.58) | 0.5789 |
| Year-8 health status | ||||
| Insulin, yes vs. no | 1.11 (0.85, 1.44) | 0.89 (0.76, 1.04) | 1.25 (0.98, 1.60) | 0.0307 |
| Frailty index, ≥0.21 vs. <0.21 | 1.15 (0.91, 1.48) | 1.24 (1.08, 1.42) | 1.97 (1.57, 2.47) | <0.0001 |
| Multimorbidity index, ≥2 vs. 0–1 | 1.43 (0.75, 2.73) | 1.46 (1.04, 2.05) | 20.2 (2.8, 145.72) | 0.0046 |
| Depressive symptoms, ≥10 vs. <10 | 1.86 (1.36, 2.55) | 1.27 (1.36, 2.55) | 1.48 (1.09, 2.01) | 0.0004 |
| Year-8 health status adjusted for baseline demographic and health characteristics | ||||
| Insulin, yes vs. no | 0.94 (0.69, 1.29) | 0.80 (0.66, 0.95) | 1.01 (0.75, 1.35) | 0.0752 |
| Frailty index, ≥0.21 vs. <0.21 | 1.18 (0.89, 1.55) | 1.18 (1.01, 1.37) | 1.70 (1.31, 2.19) | 0.0007 |
| Multimorbidity index, ≥2 vs. 0–1 | 1.10 (0.55, 2.20) | 1.22 (0.84, 1.76) | 11.00 (1.5, 80.62) | 0.0982 |
| Depressive symptoms, ≥10 vs. <10 | 1.84 (1.32, 2.58) | 1.26 (1.02, 1.56) | 1.44 (1.03, 2.00) | 0.0019 |
Data are presented as OR (95% CI). Baseline demographic characteristics were age and randomization arm, and baseline health characteristics were BMI, diabetes duration, insulin use, frailty, multimorbidity, and depressive symptoms (BDI). Bold font indicates that the comparison is statistically significant.