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. 2022 Jun 29;12:935806. doi: 10.3389/fcimb.2022.935806

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Copyright © 2022 Groeger, Wu, Wagenlehner, Dansranjav, Ruf, Denter and Meyle

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical inhibition of PD-L1 expression: (A) Western blot of Signaling pathway of PD-L1 expression was investigated by SP00125, a specific inhibitor of JNK (MAP kinase pathway) and Gefitinib an RIP2 (NOD pathway) inhibitor. (B) Signaling pathway of P. gingivalis induced PD-L1 expression was investigated using SP00125, a specific inhibitor of JNK (MAP kinase pathway) and Gefitinib an RIP2 (NOD pathway) inhibitor. TM = total membrane. (n=3), ** indicates corrected p < 0.01 compared to control. (C) The prostate cancer cell line DU-145 expresses NOD1 and NOD2 receptors. NOD1/NOD2 receptors protein expression in prostate cancer cell line DU145 was investigated using Western blot (n=3).