TABLE 1.
Factors impacting aNSPC cell cycle activity in the zebrafish CNS.
| Regulator | Stem cell niche | aNSPC | Δ cell cycle | References |
|---|---|---|---|---|
| Telencephalon | ||||
| a Estrogen | Whole brain | RGC & NEC | Decrease | Makantasi and Dermon, (2014) |
| Tank enrichment | Whole Tel | RGC & NEC | Increase | von Krogh et al. (2010) |
| Male social subordination | DP | RGC | Decrease | Tea et al. (2019) |
| Social stimulation | DP, PoA | RGC | Increase | Dunlap et al. (2021) |
| GnRH | PoA | RGC & NEC | Increase | Ceriani and Whitlock, (2021) |
| Dorsal stab lesion | Tel | RGC | Increase | Kroehne et al. (2011); Kishimoto et al. (2012); Barbosa et al. (2015) |
| cxcr5 knock-down | DP (injury) | RGC | Decrease | Kizil et al. (2012a) |
| Gata3 knock-down | DP (injury) | RGC | Decrease | Kizil et al. (2012b) |
| BMP/Id1 | DP (homeostasis and injury) | RGC | Maintain quiescence | Rodriguez Viales et al. (2015), Zhang et al., 2021 |
| Mdka | DP (homeostasis and injury) | RGC | Quiescence | Lübke et al. (2022) |
| Notch | DP (homeostasis and injury) | RGC | Quiescence | Chapouton et al. (2010); Anand and Mondal, (2017) |
| Inflammation | DP (homeostasis and injury) | RGC | Increase | Kyritsis et al. (2012) |
| Chronic hyperglycemia | Tel (homeostasis and injury) | RGC | Decrease | Dorsemans et al. (2017), Ghaddar et al. (2021) |
| Amyloid-β-42 | Tel | RGC & NEC | Increase | Cosacak et al. (2019); Bhattarai et al. (2020) |
| Serotonin | Tel (AD model) | RGC | Decrease | Bhattarai et al. (2020) |
| BDNF | Tel (AD model) | RGC | Increase | Bhattarai et al. (2020) |
| IL-4/STAT6 | Tel (AD model) | RGC | Increase | Bhattarai et al. (2020) |
| Serotonin promotion | PoA | RGC | Increase | Thompson et al. (2017) |
| Midbrain | ||||
| Visual deprivation | TeO | NEC | Decrease | Lindsey et al. (2014); Boulanger-Weill et al. (2017); Hall and Tropepe, (2018a) |
| Serotonin inhibition | H | RGC | Decrease | Pérez et al. (2013) |
| Serotonin promotion | H | RGC | Increase | Thompson et al. (2017) |
| Injury | TeO | RGC | Increase | Shimizu et al. (2018); Lindsey et al. (2019) |
| IL6/Stat3 | TeO (injury) | RGC | Increase | Shimizu et al. (2021) |
| Injury | TeO | NEC | Increase | Shimizu et al. (2018); Lindsey et al. (2019) |
| Chronic hyperglycemia | MB | RGC & NEC | Decrease | Dorsemans et al. (2017) |
| Chronic starvation | TeO | NEC | Decrease | Benítez-Santana et al. (2016) |
| Corpus Cerebelli and Spinal Cord | ||||
| Injury | CCe | RGC & NEC | Increase | Kaslin et al. (2017) |
| Chronic hyperglycemia | CCe | RGC & NEC | Decrease | Stankiewicz et al. (2017) |
| Exercise | SC | RGC | Increase | Chang et al. (2021) |
| Injury | SC | RGC | Increase | Reimer et al. (2009) |
a
Brain-wide stem cell niches affected.
Only studies showing a significant effect on aNSPC proliferation are listed. Tel, Telencephalon; DP, dorsal pallium; PoA, preoptic area; AD, Alzheimer’s Disease; TeO, optic tectum; H, hypothalamus; MB, midbrain; CCe, corpus cerebelli; SC, spinal cord; RGC, radial-glial cells; NEC, neuro-epithelial cells.