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. 2022 Jun 29;9:922428. doi: 10.3389/fmolb.2022.922428

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Copyright © 2022 Agborbesong, Li, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The molecular mechanism of ferroptosis. Ferroptosis is an iron dependent form of cell death. The metabolism of iron includes iron uptake (transferrin receptor), iron export (ferroportin), iron storing (ferritin), and ferritinophagy. Ferritinophagy is a selective autophagy of ferritin which mediated by Atg5/7 and NCOA4. Excess can directly induce ferroptosis through lipid peroxidation. GPX4, converts PEAA/AdA-OOH to PEAA/AdA-OH and inhibits ferroptosis. This reaction occurs through the use of glutathione (GSH) as a substrate.