TABLE 2.

Summary of clinical trials and preclinical studies targeting epigenetic factors in ADPKD.

Drug	Mediator	Status	Clinical outcome or animal model	Reference
Niacinamide	SIRT1	Phase 2	TKV, eGFR, pain score, urine MCP-1	NCT02558595
Valproic acid	HDAC	Preclinical	Pkd1 mutant mice	Cao et al. (2009)
JQ1	Brd4	Preclinical	Pkd1 mutant mice	Zhou et al. (2015)
AZ505	Smyd2	Preclinical	Pkd1 mutant mice	Li et al. (2017b)

Abbreviations used: TKV, total kidney volume; eGFR, estimated glomerular filtration rate; MCP-1, monocyte chemoattractant protein-1.