Table 2.
ACE 2 Location and Subcellular Staining Patterns.
| Organ | Cellular Location | Stain Location | ||
|---|---|---|---|---|
| Nuclear | Cytoplasmatic | Membranous | ||
| Lung | Pneumocytes | + | + | - |
| Macrophages | - | + | - | |
| Respiratory epithelium | + | + | + | |
| Heart | Cardiomyocytes | - | + | + (also Z-line) |
| Stomach | Follicular and glandular epithelium | - | + | + |
| Ganglion cells | + | - | - | |
| Small intestine | Epithelium | - | + | + |
| Lymphoid tissue | + | - | - | |
| Ganglion cells | + | - | - | |
| Liver | Kupffer cells | + | + | - |
| Bile ducts | - | + | + | |
| Hepatocytes | Weak, negative | Weak, negative | - | |
| Pancreas | Acini (sporadically) | - | - | + |
| Ducts | - | - | + | |
| Kidneys | Cortical tubuli a | - | + | + |
| Bowman’s capsule | + (endothelium) | + (epithelium, endothelium) | - | |
| Adrenal glands | Zona glomerulosa | - | + | - |
| Zona fasciculate | + | + | - | |
| Zona reticularis | - | + | - | |
| Brain | Astrocytes | - | - | + |
Endothelium of blood vessels was ACE2 protein-immunoreactive in all organs.
aDifference in expression between distal (overt expression of luminal surface and cytoplasm basal and luminal surface) and proximal (much less, cytoplasmatic and nuclear) tubuli.