Table 6.
Septic COD 24 (64%) | Non-septic COD 14 (37%) | |
---|---|---|
Type of autopsy examination | ||
Hospital (pre-/post-2010) | 2/0 | 2/2 |
Coroner (pre-/post-2010) | 19/3 | 6/4 |
Terminal events | ||
Found unresponsive at home | 3 | 2 |
Witnessed sudden collapse at home or in ambulance | 7 | 1 |
Reached hospital | 14 | 11 |
Died ≤1 day of admission | 13 | 8 |
Died >1 day of admission | 1 | 3 |
Terminal clinical assessment— | ||
Signs or diagnosis of sepsis | 14 | |
Seizure and other CNS symptoms | 6 | |
Respiratory distress | 4 | |
Features suggestive of viral gastroenteritis | 1 | |
Premortem cultures | ||
Positive | 11 a | 10 |
Negative | 1 | |
Premortem antibiotic therapy | 6 | 9 |
Postmortem findings | ||
Stigmata of sepsis | 24 | |
Tissue or organ inflammation | 12 | 14 |
Postmortem cultures | ||
PMBC (n = 35) | ||
Pure growth | 15 | 2 |
Sterile | 6 | 5 |
Contamination | 3 | 4 |
PMLC (n = 34) | ||
Pure growth | 9 | 4 d |
Sterile | 1 | 2 |
Contamination | 13 b | 5 e |
Postmortem CSF (n = 15) | ||
Pure growth | 2 | 2 f |
Sterile | 7 c | 3 f |
Contamination | 1 | 0 |
Septic category included deaths due to sepsis (n = 12) and sepsis with underlying pneumonia (n = 6), meningitis (n = 2), lung abscess (n = 1), ruptured retrocecal appendicitis with abscess formation (n = 1), large cavitating abscess of the right side of the neck with septic emboli in both lungs (n = 1) and acute purulent peritonitis (n = 1). Non-septic category included deaths due to pneumonia (n = 7), meningitis (n = 6), and diffuse purulent peritonitis (n = 1).
Abbreviations: PMBC, postmortem blood culture; PMLC, postmortem lung culture; CSF, Cerebrospinal fluid.
aIncluded three blood samples taken at time of resuscitation.
bIncluded deaths due to sepsis with underlying pneumonia (n = 2).
csepsis with underlying meningitis (n = 1).
dpneumonia (n = 4).
epneumonia (n = 3).
fmeningitis (n = 2).