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. 2022 Feb 28;25(4):409–418. doi: 10.1177/10935266211064696

Table 6.

Summary Table of Findings by Cause of Death (COD).

Septic COD 24 (64%) Non-septic COD 14 (37%)
Type of autopsy examination
 Hospital (pre-/post-2010) 2/0 2/2
 Coroner (pre-/post-2010) 19/3 6/4
Terminal events
 Found unresponsive at home 3 2
 Witnessed sudden collapse at home or in ambulance 7 1
 Reached hospital 14 11
 Died ≤1 day of admission 13 8
 Died >1 day of admission 1 3
Terminal clinical assessment—
 Signs or diagnosis of sepsis 14
 Seizure and other CNS symptoms 6
 Respiratory distress 4
 Features suggestive of viral gastroenteritis 1
Premortem cultures
 Positive 11 a 10
 Negative 1
Premortem antibiotic therapy 6 9
Postmortem findings
 Stigmata of sepsis 24
 Tissue or organ inflammation 12 14
Postmortem cultures
PMBC (n = 35)
 Pure growth 15 2
 Sterile 6 5
 Contamination 3 4
PMLC (n = 34)
 Pure growth 9 4 d
 Sterile 1 2
 Contamination 13 b 5 e
Postmortem CSF (n = 15)
 Pure growth 2 2 f
 Sterile 7 c 3 f
 Contamination 1 0

Septic category included deaths due to sepsis (n = 12) and sepsis with underlying pneumonia (n = 6), meningitis (n = 2), lung abscess (n = 1), ruptured retrocecal appendicitis with abscess formation (n = 1), large cavitating abscess of the right side of the neck with septic emboli in both lungs (n = 1) and acute purulent peritonitis (n = 1). Non-septic category included deaths due to pneumonia (n = 7), meningitis (n = 6), and diffuse purulent peritonitis (n = 1).

Abbreviations: PMBC, postmortem blood culture; PMLC, postmortem lung culture; CSF, Cerebrospinal fluid.

aIncluded three blood samples taken at time of resuscitation.

bIncluded deaths due to sepsis with underlying pneumonia (n = 2).

csepsis with underlying meningitis (n = 1).

dpneumonia (n = 4).

epneumonia (n = 3).

fmeningitis (n = 2).