Table 3.

Adjusted HRs of A1c TIR predicting incident macrovascular complications

Main predictor	Macrovascular (n=89 625)	Cardiovascular (n=122 135)	Cerebrovascular (n=277 234)	Peripheral vascular (n=228 583)
A1c TIR	*	*	*	*
80% to 100%	1.00	1.00	1.00	1.00
60% to <80%	1.05* (1.02–1.08)	1.02 (0.99–1.05)	1.05* (1.02–1.08)	1.09* (1.06–1.13)
40% to <60%	1.03* (1.00–1.06)	1.01 (0.99–1.04)	1.08* (1.05–1.11)	1.09* (1.05–1.12)
20% to <40%	1.05* (1.02–1.08)	1.05* (1.02–1.08)	1.07* (1.04–1.10)	1.09* (1.06–1.12)
0% to <20%	1.08* (1.05–1.11)	1.08* (1.05–1.11)	1.09* (1.07–1.12)	1.12* (1.09–1.15)
A1c SD	1.00 (0.98–1.03)	1.00 (0.98–1.02)	0.98 (0.97–1.00)	0.99 (0.97–1.01)
A1c mean	1.05* (1.04–1.06)	1.05* (1.04–1.06)	1.08* (1.07–1.09)	1.11* (1.10–1.12)

*P<0.05.

A1c, hemoglobin A1c; TIR, time in range.