Table 3.
Adjusted HRs of A1c TIR predicting incident macrovascular complications
Main predictor | Macrovascular (n=89 625) |
Cardiovascular (n=122 135) |
Cerebrovascular (n=277 234) |
Peripheral vascular (n=228 583) |
A1c TIR | * | * | * | * |
80% to 100% | 1.00 | 1.00 | 1.00 | 1.00 |
60% to <80% | 1.05* (1.02–1.08) | 1.02 (0.99–1.05) | 1.05* (1.02–1.08) | 1.09* (1.06–1.13) |
40% to <60% | 1.03* (1.00–1.06) | 1.01 (0.99–1.04) | 1.08* (1.05–1.11) | 1.09* (1.05–1.12) |
20% to <40% | 1.05* (1.02–1.08) | 1.05* (1.02–1.08) | 1.07* (1.04–1.10) | 1.09* (1.06–1.12) |
0% to <20% | 1.08* (1.05–1.11) | 1.08* (1.05–1.11) | 1.09* (1.07–1.12) | 1.12* (1.09–1.15) |
A1c SD | 1.00 (0.98–1.03) | 1.00 (0.98–1.02) | 0.98 (0.97–1.00) | 0.99 (0.97–1.01) |
A1c mean | 1.05* (1.04–1.06) | 1.05* (1.04–1.06) | 1.08* (1.07–1.09) | 1.11* (1.10–1.12) |
*P<0.05.
A1c, hemoglobin A1c; TIR, time in range.