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. 2022 May 26;113(7):2272–2287. doi: 10.1111/cas.15378

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© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of lenvatinib and erastin on ferroptosis pathways and cell survival lenvatinib (HuH7: 0.8 µM, Hep3B: 0.4 µM) and erastin (10 µM) inhibited the expression of system X_c ⁻ (xCT) and glutathione peroxidase 4 (GPX4) (A), increased lipid reactive oxygen species (ROS) accumulation, and suppressed cell survival (B). Si‐fibroblast growth factor receptor 4 (FGFR4) inhibited the expression of xCT and GPX4 (C), increased lipid ROS accumulation, and suppressed cell survival (D). *P < 0.01 versus the control group. Ctrl, control; fer1, ferrostatin‐1