TABLE 3.

MiRNAs in membranous nephropathy.

MiRNA	Dysregulation	Target	In vitro model	In vivo model	Effects	Reference
miR-186	Down	P2X7	Podocytes	MN patients	Antiapoptotic effect of podocytes	Sha et al. (2015)
miR-217	Down	TNFSF11	Podocytes	MN patients	As a useful diagnostic biomarker	Li et al. (2017)
miR-130a-5p	Down	PLA2R	Podocytes	MN patients MN mice	Prevents angiotensin II-induced podocyte apoptosis	Liu et al. (2018)
miR-98 miR-375	Up	—	—	MN patients	As novel biomarkers for the diagnosis and treatment	Chen et al. (2014)
miR-7-5p miR-615-3p miR-577	Down	—	—	MN patients	As novel biomarkers for the diagnosis and treatment	Chen et al. (2014)
let-7a-5p let-7c-5p	Up	IL6 MYC	—	MN patients	As potential diagnostic biomarkers	Barbagallo et al. (2019)
miR-195-5p	Up	PPM1A	—	MN patients	As a potential biomarker	Zhou et al. (2019)
miR-192-3p	Up	RAB1A	—	MN patients	As a potential biomarker	Zhou et al. (2019)
miR-328-5p	Down	BRSK1	—	MN patients	As a potential biomarker	Zhou et al. (2019)
miR-106a miR-19b	Down	PTEN	—	MN patients	As new biomarkers for the diagnosis of MN	Wu et al. (2021)