TABLE 4.

MiRNAs in diabetic kidney disease.

MiRNA	Dysregulation	Target	In vitro model	In vivo model	Effects	Reference
miR-23b	Down	G3BP2	Podocytes	DKD patients DKD mice	Exerts protective effects against podocyte injury	Zhao et al. (2016)
miR-25	Down	CDC42	Podocytes	DKD patients DKD mice	Shows protective effects against podocyte injury	Liu et al. (2017)
miR-10a/b	Down	NLRP3	Podocytes	DKD patients DKD mice	Negatively regulates inflammation in diabetic kidney	Ding et al. (2021)
miR-146a	Down	Notch1 ErbB4	Podocytes	DKD mice	As a biomarker for disease progression	Lee et al. (2017)
miR-29a	Down	HDAC4	Podocytes	DKD mice	Ameliorates diabetes-induced podocyte injury	Lin et al. (2014)
miR-93	Down	Msk2	Podocytes	DKD patients DKD mice	Attenuates podocyte injury	Badal et al. (2016)
miR-27a	Up	PPARγ	Podocytes	DKD patients DKD rats	Promotes podocyte injury	Zhou et al. (2017)
miR-21	Up	PTEN	Podocytes	DKD patients DKD mice	Promotes podocyte dysfunction	Kölling et al. (2017)
miR-29c	Up	SPRY1	Podocytes	DKD mice	As a novel therapeutic target in diabetic nephropathy	Long et al. (2011)
miR-182-5p	Up	CD2AP	Podocytes	DKD patients	Induces podocyte apoptosis	Ming et al. (2019)
miR-20b	Up	SIRT7	Podocytes	—	Contribute to HG-induced podocytes apoptosis	Wang et al. (2017)
miR-503	Up	E2F3	Podocytes	DKD rats	Contributes to podocyte injury	Zha et al. (2019)
miR-193a	Up	APOL1	Podocytes	—	Prevents podocytes dedifferentiation in HG condition	Mishra et al. (2018)