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. 2022 Jun 28;24(6):e32997. doi: 10.2196/32997

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©Florian Lipsmeier, Cedric Simillion, Atieh Bamdadian, Rosanna Tortelli, Lauren M Byrne, Yan-Ping Zhang, Detlef Wolf, Anne V Smith, Christian Czech, Christian Gossens, Patrick Weydt, Scott A Schobel, Filipe B Rodrigues, Edward J Wild, Michael Lindemann. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 28.06.2022.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

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Clinical validity of digital whole body and lower limb tests. (A) Comparison of the balance score with the logarithm of the sway path based on smartphone signal while standing still. (B) Comparison of Unified HD Rating Scale-Total Motor Score (UHDRS-TMS) with the median turn speed during the U-Turn test. (C) Comparison of the UHDRS-TMS with the step frequency variance during the Walking test. The dotted line in (B) and (C) shows the regression line. ^aHigher scores represent increased clinical worsening. ^bBalance is the sum of UHDRS-TMS Retropulsion Pull test item and UHDRS-TMS Tandem Walking test item scores. HD: Huntington disease; NHS: Natural History Study; OLE: open-label extension.