Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 29;13:930963. doi: 10.3389/fimmu.2022.930963

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Provin and Giraud

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A synthesis of pluripotent stem cells thymic differentiation strategies. A decade of advances in thymic differentiation resulted in perfected protocols allowing production of mature mTEC by mimicking the thymic organogenesis in vitro. For each reference, cell type used, pathway-modulating molecules timings and concentrations are indicated, as well as results in terms of nature of the obtained cells and their ability to induce T cell maturation. ActivinA (ActA), Fibroblast growth factors 7,8,10 (FGF7-8-10), Bone Morphogenetic Protein 4 (BMP4), LiCl (Lithium Chloride), Retinoic acid (RA), Cyclopamine (CPM, hedgehog inhibitor), Sonic Hedgehog (SHH), LY364947 (TGFβ inhibitor), SB43 (TGFβ inhibitor), Wingless family member 3 (WNT3), IWR1 (WNT inhibitor), Epidermal Growth Factor (EGF), CHIR99 (WNT3 agonist), LDN19 (BMP inhibitor), Noggin (NOG), SANT1 (Hedgehog inhibitor), Smoothened Agonist (SAG, Hedgehog agonist).