< 6 years	6–12 years	12–18 years
Pediatric endocrinology consultation	/1–3 years without GH	/1 year without GH	/6 months
	/6 months on rhGH	/6 months on rhGH
Clinical examination	1x/year	/6 months on rhGH (1x/year without rhGH)	/6 months on rhGH (1x/year without rhGH)
Measurement of BP	1x/year	1x/year	1x/year
Screening for kyphosis, scoliosis (starting at 8–10 yrs++)	1x/year	1x/year	1x/year
	Every 6 months on GH	Every 6 months on rhGH	Every 6 months on rhGH
Standard and Turner growth curves	1x/year	At each visit	At each visit
Serum IGF-I determination	Start of GH treatment	Start of GH treatment
	/12 months on rhGH treatment	/12 months on rhGH treatment
Serum estradiol, FSH, LH, AMH determinations			Check before inducing puberty or 1x/year if puberty is spontaneous
Anti-TPO Ab	From the age of 4 years	1x/year
TSH, ± FT4	From the age of 4 years	If treating hypo- or hyperthyroidism: TSH, FT4: every 3–12 months
HbA1c		> 10 years: 1x/year HbA1C/3 months if diabetic
± blood glucose levels
± fasting insulinemia
± OGTT	Before rhGH treatment if glycemia or HbA1c levels moderately high	OGTT before rhGH treatment if risk factors and if glycemia or HbA1c levels moderately high
AST, ALT, gamma-GT		> 6 years:
		6–10 years 1 × every 2 years
		> 10 years: 1x/year
IgA antitransglutaminases, total IgA	> 2 years: 1 × every 2 years	1 × every 2 years	1 × every 2 years
Total cholesterol/HDLc/LDLc/Triglycerides		> 10 years: 1 × every 3–4 years	1 × every 3–4 years
Creatininemia, Microalbumin/creatinine in urine	If renal malformation or HBP
25(OH)D	/2–3 years	/2–3 years	/2–3 years
Consultation with (pediatric) cardiologist, with cardiac ultrasound	Depending on heart disease/condition	1x/year if cardiopathy or HBP
		1 × every 5 years: systematically if no risk factors
		Systematically before transition to adult care
Aortic and cardiac MRI	As advised by the cardiologist	As advised by the cardiologist
Thyroid ultrasound	If there is dysthyroidism, palpable nodule, and/or goiter
ENT consultation and hearing evaluation	1x/year if recurrent bouts of otitis	As advised by ENT, with consultation at least once every 5 years provided there are no risk factors
Ophthalmologic consultation	Systematic screening between 12 and 15 months and between 3 and 4 years (as in the general population)	Consultation only if necessary: suspicious signs, sensory or motor abnormality, follow-up for strabismus, follow-up of refractive abnormalities, follow-up for organic abnormality
Dermatological consultation	As a function of symptoms
Bone age	1 × every 2 to 3 years in case of rhGH treatment
Bone densitometry		Check-up at end of the growth period or puberty
Pelvic ultrasound		Check-up at end of the growth period or puberty
Dental consultation	Annually, with adjustment according to clinical profile	Annually, with adjustment according to clinical profile
Consultation with a dietitian	If overweight, carbohydrate intolerance, diabetes, dyslipidemia
	Supplementation with calcium and vitamin D, if necessary
Screening for behavioral problems	Every year, during the clinical evaluation
Psychological consultation	Around the age of 4–5 years (before, if there are suspicious signs)	Every 5 years, with re-evaluation as a function of symptoms
± Psychometric tests
Therapeutic education	Every 1–2 years and as required
Gynecology consultation		During puberty induction, then every 2–3 years