Table 2.

CircRNAs involved in drug resistance in GC

CircRNA	CircBase ID	Drug	Expression	Drug resistance	Targets	Refs
circVAPA	hsa_circ_0006990	Cisplatin	Up	Enhance	miR-125b-3p, STAT3	[97]
circAKT3	hsa_circ_0000199	Cisplatin	Up	Enhance	miR-198, PIK3R1	[55]
circARVCF	hsa_circ_0092330	Cisplatin	Up	Enhance	miR-1205, FGFR1	[98]
circCCDC6	hsa_circ_0001313	Cisplatin	Up	Enhance	miR-618, BCL-2	[99]
circFN1	hsa_circ_0058147	Cisplatin	Up	Enhance	miR-182-5p	[100]
circPVT1	-	Cisplatin	Up	Enhance	miR-30a-5p, YAP1	[101]
circ_0000260	hsa_circ_0000260	Cisplatin	Up	Enhance	miR-129-5p, MMP11	[102]
circ_0032821	hsa_circ_0032821	Oxaliplatin	Up	Enhance	miR-515-5p, SOX9	[103]
circPVT1	-	Paclitaxel	Up	Enhance	miR-124-3p, ZEB1	[104]
circNRIP1	hsa_circ_0004771	5-fluorouracil	Up	Enhance	miR-138-5p, HIF-1α	[105]
circDLG1	hsa_circ_0008583	anti-PD-1	Up	Enhance	miR-141-3p, CXCL12	[106]
circCUL2	hsa_circ_0000234	Cisplatin	Down	Suppress	miR-142-3p, ROCK2	[107]
circMCTP2	hsa_circ_0000657	Cisplatin	Down	Suppress	miR-99a-5p, MTMR3	[108]
circ_0000144	hsa_circ_0000144	Oxaliplatin	Down	Suppress	miR-502-5p, ADAM9	[109]
circ_0000376	hsa_circ_0000376	Bupivacaine	Down	Suppress	miR-145-5p	[110]
circ_0000520	hsa_circ_0000520	Herceptin	Down	Suppress	PI3K-AKT pathway	[111]