Table 3.
IGSF11 and VISTA targeted drugs
| Tumor | Target | Drug | Mechanisms | PMID |
|---|---|---|---|---|
| Gastric cancer | IGSF11 | Polypeptide Vaccine | Enhance the Function of CTLs | 16,108,831 |
| Melanoma | IGSF11 | SG7 | Inhibit the interaction between VISTA and IGSF11 | 32,938,950 |
| Colon Carcinoma | IGSF11/PD1 | SG7 combined with anti-PD1 | Inhibit the interaction between VISTA and IGSF11; anti-PD1 | 32,938,950 |
| Colon Carcinoma | VISTA/PD-L1 | VISTA-Ig and PD-L1 Ig | anti-VISTA and anti-PD-L1 | 25,964,334 |
| Enhance the response of T cells | ||||
| Increase the count of T cells | ||||
| Boost antigen presentation | ||||
| Advanced Solid Tumors or Lymphomas | VISTA/KRAS | CA170 and KRAS peptide vaccine | Boost the infiltration of CD8 + T cells | 34,302,042 |
| Decrease the infiltration of MDSCs | ||||
| Decrease the infiltration of Tregs | ||||
| Inhibit lung tumorigenesis | ||||
| Solid tumor | VISTA | CI-8993 | anti-VISTA | 33,937,071 |
| Melanoma | VISTA | 13F3 | Inhibit the proliferation of tumor | 24,691,994 |
| Induce the apoptosis of tumor cells | ||||
| Increase the count of IFN-γ producing cells | ||||
| Promote the response of tumor specific T cells | ||||
| Melanoma | VISTA | αVISTA | Increase the count of CD4 + and CD8 + T cells | 24,691,994 |
| Decrease the infiltration of MDSCs | ||||
| Bladder tumor | VISTA | 13F3 | Activate tumor-associated CD11c + DCs | 24,691,994 |
| Induce the production of IL-12 and TNF-α | ||||
| Decrease the count of Foxp3GFP + iTregs | ||||
| Directly inhibit Tregs activation | ||||
| Enhance the proliferation and cytotoxic function of CD8 + T cells | ||||
| Mouse model | VISTA | 6809–0223 | Promote the proliferation of CD4 + T cell | 34,380,434 |
| Induce the production of IL-2 from both CD4 + and CD8 + T cell | ||||
| Induce the production of IL-4, IFN-γ and TNF-α from CD8 + T cell | ||||
| Colon cancer | VISTA | HMBD-002 | Promote the response of proinflammatory Th1 cells | 35,131,861 |
| Breast cancer | Increase the number of CD11b + macrophages, CD11c + DCs and CD8 + T cells | |||
| Colorectal cancer | ||||
| Lung cancer | ||||
| Squamous cell carcinoma | VISTA/CTLA4 | MIH63 | Activate and upregulate CD8 + T cells | 34,282,763 |
|
Converse the exhausted cells into effector CD8 + T cells |
27,208,845 | |||
| Promote the secretion of TNF- α and IFN-γ |