Table 3.

Multivariate analyses of prognostic factors of patients with advanced gastrointestinal cancers

OS	Multivariate analysis 1		Multivariate analysis 2
	HR (95% CI)	P value	HR (95% CI)	P value
Sex
Female vs male	0.87 (0.46–1.63)	P = 0.66	0.75 (0.39–1.42)	P = 0.37
Age
< 69 vs ≥ 69	0.78 (0.40–1.50)	P = 0.45	1.41 (0.65–3.06)	P = 0.39
Lymph node metastasis
Yes vs no	1.42 (0.82–2.46)	P = 0.22	1.66 (0.93–2.95)	P = 0.084
cIS1
High vs low	0.34 (0.17–0.67)	P = 0.002
cIS2
High vs low			0.14 (0.06–0.32)	P < 0.001
PFS	Multivariate analysis 1		Multivariate analysis 2
Sex
Female vs male	0.68 (0.28–1.65)	P = 0.40	0.51 (0.20–1.28)	P = 0.15
Age
< 69 vs ≥ 69	0.68 (0.30–1.46)	P = 0.31	1.38 (0.52–3.66)	P = 0.52
Lymph node metastasis
Yes vs no	2.03 (0.98–4.22)	P = 0.056	2.67 (1.26–5.68)	P = 0.10
cIS1
High vs low	0.41 (0.19–0.86)	P = 0.019
cIS2
High vs low			0.16 (0.06–0.4)	P < 0.001

The bold value indicates P < 0.05, HR Hazard ratio, CI Confidence interval, sex, age, lymph node metastasis, and cIS1 were included in multivariate analysis 1; sex, age, lymph node metastasis and cIS2 were included in multivariate analysis 2