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. 2022 Jul 12;45(11):2157–2163. doi: 10.1007/s40618-022-01857-9

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© The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2022

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 1 — Up-regulation of ACE-2 mRNA levels. A A significant up-regulation of the basal mRNA levels of ACE-2 in normal human thyroid cells in primary cultures, was registered following treatment with Vitamin D (2,4±0,9 ACE-2 mRNA fold increase; Student-T test p<0.05 Vitamin D vs. Basal); B a significant up-regulation of the basal mRNA levels of ACE-2 in normal human thyroid cells in primary cultures, was registered following treatment with IFNɣ (13,6±4,3 ACE-2 mRNA fold increase; Student-T test p<0.05 IFNɣ vs. Basal); Panel C A significant increase with the co-treatment with Vitamin D + IFNɣ was observed in terms of increase in ACE-2 mRNA levels (37,5±16,7 ACE-2 mRNA fold increase; Student-T test p<0.05 Vitamin D + IFNɣ vs. Basal)