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. 2022 Jul 13;217:492–505. doi: 10.1016/j.ijbiomac.2022.07.022

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Fig. 6 — Fuzzy clustering analysis integrating evolutionary and structural features of RBD revealed Structure Block (SB) 10 as the most important region of RBD. (A) Fuzzy clustering plot representing overlaps of the Structure Blocks depending on the cumulative contribution of structural and evolutionary features. SB1 is indicated by blue spheres, SB6 is indicated by orange spheres, SB9 is indicated by green spheres, SB10 is indicated by red spheres and SB12 is indicated by cyan spheres. SB9 and SB10 show significant overlap with all other SBs. (B) In the ACE2 receptor (green region) bound RBD structure, the most important SB, SB10 has been highlighted by red colour. Rest part of the RBD has been highlighted by slate blue colour. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)